Abstract | CONTEXT:
Ghrelin is an orexigenic hormone that can increase body weight. Its circulating levels increase before meals and are suppressed after food ingestion. Understanding the effects of specific types of ingested macronutrients on ghrelin regulation could facilitate the design of weight- reducing diets. OBJECTIVE: DESIGN: This was a randomized, within-subjects cross-over study. SETTING: The study was conducted at a University Clinical Research Center. PARTICIPANTS: There were 16 healthy human subjects included in the study. INTERVENTIONS: MAIN OUTCOME MEASURES: The magnitude of postprandial suppression of total and acyl ghrelin levels (measured with a novel acyl-selective, two-site ELISA) was determined. RESULTS: All beverages suppressed plasma acyl and total ghrelin levels. A significant effect of macronutrient class on decremental area under the curve for both acyl and total ghrelin was observed; the rank order for magnitude of suppression was protein more than carbohydrate more than lipid. Total ghrelin nadir levels were significantly lower after both carbohydrate and protein, compared with lipid beverages. In the first 3 postprandial hours, the rank order for acyl and total ghrelin suppression was carbohydrate more than protein more than lipid. In the subsequent 3 h, there was a marked rebound above preprandial values of acyl and total ghrelin after carbohydrate ingestion alone. CONCLUSIONS:
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Authors | Karen E Foster-Schubert, Joost Overduin, Catherine E Prudom, Jianhua Liu, Holly S Callahan, Bruce D Gaylinn, Michael O Thorner, David E Cummings |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 93
Issue 5
Pg. 1971-9
(May 2008)
ISSN: 0021-972X [Print] United States |
PMID | 18198223
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Chemical References |
- Dietary Carbohydrates
- Dietary Fats
- Dietary Proteins
- Ghrelin
- Insulin
- Leptin
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Topics |
- Acylation
- Adult
- Aged
- Appetite
- Area Under Curve
- Cross-Over Studies
- Dietary Carbohydrates
(pharmacology)
- Dietary Fats
(pharmacology)
- Dietary Proteins
(pharmacology)
- Female
- Ghrelin
(blood)
- Humans
- Insulin
(blood)
- Leptin
(blood)
- Male
- Middle Aged
- Time Factors
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