Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Three trials in adult Burkitt's/B-ALL showed a significant survival advantage when rituximab was added to standard chemotherapy. Minimal pediatric data have been published, but 19 children with mature B-cell lymphoma/B-ALL received rituximab, alone or in combination with chemotherapy, as salvage therapy, after failure of intensive chemotherapy. Fifteen of 19 (79%) responded, 12 (63%) remained alive in continuous complete remission at 5+ to 48+ months of follow-up. Two patients were alive in partial remission. Five patients died, four of progressive disease. Only one patient had no response to rituximab. SUMMARY:
Rituximab has demonstrated efficacy in Burkitt's disease in adults. Although positive reporting bias is suspected, it appears that rituximab, even as monotherapy, has efficacy in heavily pretreated pediatric patients with high-grade B- lymphoma/B-ALL. Rituximab use can be justified in a prospective controlled chemotherapy dose-reduction study.
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Authors | Dina Attias, Sheila Weitzman |
Journal | Current opinion in pediatrics
(Curr Opin Pediatr)
Vol. 20
Issue 1
Pg. 17-22
(Feb 2008)
ISSN: 1040-8703 [Print] United States |
PMID | 18197034
(Publication Type: Journal Article, Review)
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Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Murine-Derived
- Antineoplastic Agents
- Rituximab
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Topics |
- Adult
- Antibodies, Monoclonal
(therapeutic use)
- Antibodies, Monoclonal, Murine-Derived
- Antineoplastic Agents
(therapeutic use)
- Child
- Humans
- Lymphoma, B-Cell
(drug therapy)
- Rituximab
- Treatment Outcome
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