Anti-inflammatory and antinociceptive activity of arbortristoside-A.

Abstract

Nyctanthes arbortristis Linn is a well-documented plant. It is evident from literature and previous investigations that Nyctanthes arbortristis possesses anti-inflammatory and analgesic activity. In the present study arbortristoside-A has been isolated from the ethanolic extract of its seeds. The structure of the isolated compound was determined by chemical reactions and spectroscopic methods. Arbortristoside-A was found to possess significant and dose-dependent anti-inflammatory and antinociceptive activity. It seems arbortristoside-A inhibited the histamine, serotonin and carrageenan-induced edema suggesting its inhibiting effect on carrageenan, arachidonic acid, histamine and serotonin-induced edema suggesting its anti-inflammatory activity may be due to the inhibiting effect of prostaglandin, histamine and serotonin. The analgesic activity of arbortristoside-A may be due to the inhibition of the action of prostaglandin.

• Authors: Sanjita Das, Dinakar Sasmal, Saumya Priya Basu
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 116 Issue 1 Pg. 198-203 (Feb 28 2008) ISSN: 0378-8741 [Print] Ireland
• PMID: 18178352 (Publication Type: Journal Article)

Chemical References

• Analgesics
• Anti-Inflammatory Agents
• Iridoid Glucosides
• Iridoids
• Prostaglandin Antagonists
• arbortristoside A

Topics

• Analgesics (isolation & purification, pharmacology)
• Animals
• Anti-Inflammatory Agents (isolation & purification, pharmacology)
• Dose-Response Relationship, Drug
• Iridoid Glucosides
• Iridoids (isolation & purification, pharmacology)
• Mice
• Oleaceae (chemistry)
• Prostaglandin Antagonists (pharmacology)
• Rats
• Rats, Wistar
• Seeds (chemistry)