Abstract |
The synthetic vasopressin analogue (1-deamino-8-D-arginine-vasopressin) increases plasma concentration of factor VIII and von Willebrand factor in normal subjects and patients with mild haemophilia A and von Willebrand disease. Since its first clinical use in 1977, desmopressin has become the treatment of choice for patients with haemophilia A and factor VIII coagulant activity (FVIII:C) > 5% and has spared several patients the risk of acquiring blood-borne viral infections due to the use of non-virally inactivated plasma-derived FVIII concentrates. An average two to sixfolds FVIII:C increase is typically observed in most patients and return to baseline occurs usually within 8 hours. Several clinical studies have demonstrated the clinical efficacy and safety of desmopressin and the availability of concentrated formulation for subcutaneous injection and of a nasal spray has paved the way to home-treatment. However, overall it appears that haemophilic children may have a lower rate of biologic response compared to adults and a minority of adult patients are not able to attain clinically useful FVIII:C levels post- desmopressin administration. Thus, in every patient with haemophilia A likely to be treated or candidate to an elective invasive procedure, a test-infusion/injection should be carried out to assess the future usefulness of the compound.
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Authors | G Castaman |
Journal | Haemophilia : the official journal of the World Federation of Hemophilia
(Haemophilia)
Vol. 14 Suppl 1
Pg. 15-20
(Jan 2008)
ISSN: 1365-2516 [Electronic] England |
PMID | 18173690
(Publication Type: Journal Article, Review)
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Chemical References |
- Hemostatics
- Deamino Arginine Vasopressin
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Topics |
- Administration, Intranasal
- Adult
- Child
- Deamino Arginine Vasopressin
(administration & dosage, therapeutic use)
- Hemophilia A
(drug therapy)
- Hemostatics
(administration & dosage, therapeutic use)
- Humans
- Injections, Intravenous
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