Abstract | BACKGROUND & OBJECTIVE: New smear-positive pulmonary tuberculosis (PTB) patients in the Revised National Tuberculosis Control Programme (RNTCP) are treated with a 6-month short-course chemotherapy (SCC) regimen irrespective of co-morbid conditions. We undertook this retrospective analysis to compare sputum conversion rates (smear, culture) at the end of intensive phase (IP) of Category-1 regimen among patients admitted to concurrent controlled clinical trials: pulmonary tuberculosis alone (PTB) or with type 2 diabetes mellitus (DM-TB) or HIV infection (HIV-TB), and to identify the risk factors influencing sputum conversion. METHODS: In this retrospective analysis sputum conversion rates at the end of intensive phase (IP) in three concurrent studies undertaken among PTB, DM-TB and HIV-TB patients, during 1998 - 2002 at the Tuberculosis Research Centre (TRC), Chennai, were compared. Sputum smears were examined by fluorescent microscopy. HIV infected patients did not receive anti-retroviral treatment (ART). Patients with DM were treated with oral hypoglycaemic drugs or insulin (sc). RESULTS: The study population included 98, 92 and 88 patients in the PTB, DM-TB and HIV-TB studies. At the end of IP the smear conversion (58, 61, and 62%) and culture conversion (86, 88 and 92%) rates were similar in the three groups respectively. The variables associated with lack of sputum smear or culture conversion were age >45 yr, higher pre-treatment smear and culture grading, and extent of the radiographic involvement. INTERPRETATION & CONCLUSION: Our findings confirm that the current policy of the control programme to treat all pulmonary TB patients with or with out co-morbid conditions with Category-I regimen appears to be appropriate.
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Authors | V V Banu Rekha, Rani Balasubramanian, Soumya Swaminathan, Rajeswari Ramachandran, Fathima Rahman, V Sundaram, K Thyagarajan, N Selvakumar, A R Adhilakshmi, Sheik Iliayas, P R Narayanan |
Journal | The Indian journal of medical research
(Indian J Med Res)
Vol. 126
Issue 5
Pg. 452-8
(Nov 2007)
ISSN: 0971-5916 [Print] India |
PMID | 18160750
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Antitubercular Agents
(therapeutic use)
- Comorbidity
- Diabetes Mellitus, Type 2
(physiopathology)
- Female
- HIV Infections
(physiopathology)
- Humans
- India
- Male
- Middle Aged
- Retrospective Studies
- Risk Factors
- Sputum
(microbiology)
- Treatment Outcome
- Tuberculosis, Pulmonary
(drug therapy)
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