Abstract | BACKGROUND: Using a transcriptional profiling approach, we recently identified myeloid-related protein 8/14 (MRP-8/14) to be expressed by platelets during acute myocardial infarction (MI). Elevated concentrations of MRP-8/14 are associated with a higher risk for future cardiovascular events in apparently healthy individuals but have not been assessed with respect to prognosis in patients with acute coronary syndrome. METHODS: RESULTS: Patients with cardiovascular death or MI after 30 days (cases) had higher median [25th, 75th percentile] MRP-8/14 levels than patients who remained free of recurrent events (5.6 [2.8, 13.5] mg/L vs 4.0 [1.9, 10.1] mg/L, P = .020). The risk of a recurrent cardiovascular event increased with each increasing quartile of MRP-8/14 (P-trend = 0.007) such that patients with the highest levels had a 2.0-fold increased odds (95% CI 1.1-3.6, P = .029) of a recurrent event after adjusting for standard risk indicators, randomized treatment, and C-reactive protein. Patients with elevated levels of MRP-8/14 and high-sensitivity C-reactive protein showed significantly increased risk of cardiovascular death or MI compared with patients with the lowest levels of both markers (adjusted odds ratio 2.1, 95% CI 1.2-3.8). CONCLUSIONS: Myeloid-related protein 8/14 may be a useful biomarker of platelet and inflammatory disease activity in atherothrombosis and may serve as a novel target for therapeutic intervention.
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Authors | David A Morrow, Yunmei Wang, Kevin Croce, Masashi Sakuma, Marc S Sabatine, Huiyun Gao, Aruna D Pradhan, Aileen M Healy, Jacki Buros, Carolyn H McCabe, Peter Libby, Christopher P Cannon, Eugene Braunwald, Daniel I Simon |
Journal | American heart journal
(Am Heart J)
Vol. 155
Issue 1
Pg. 49-55
(Jan 2008)
ISSN: 1097-6744 [Electronic] United States |
PMID | 18082488
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents
- Biomarkers
- Calgranulin A
- Calgranulin B
- Heptanoic Acids
- Pyrroles
- Atorvastatin
- Pravastatin
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Topics |
- Acute Coronary Syndrome
(blood, drug therapy, mortality)
- Aged
- Anti-Infective Agents
(administration & dosage)
- Atorvastatin
- Biomarkers
(blood)
- Calgranulin A
(blood)
- Calgranulin B
(blood)
- Case-Control Studies
- Confidence Intervals
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Heptanoic Acids
(administration & dosage)
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(blood, drug therapy, mortality)
- Odds Ratio
- Pravastatin
(administration & dosage)
- Probability
- Pyrroles
(administration & dosage)
- Reference Values
- Risk Assessment
- Survival Rate
- Thrombolytic Therapy
(methods)
- Treatment Outcome
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