[The empirical study of Maxingganshi decoction and its compatibility in acute lung injury rats].

Abstract

OBJECTIVE:

To explore the pharmacodyniamic action and the mechanism of action of the Maxingganshi decoction in acute lung injury rats in order to supply the pharmacology evidence to cure the SIRS-ALI of Maxingganshi decoction.

METHODS:

The study designed by orthogonal design. The SIRS-ALI model were Conseructed by the LPS intravenous injection and the effects of Maxingganshi decoction and it's different compatibilities to the SIRS-ALI model were observed. The experiments results were analvsised in order to reveal the compatibility rules of the Maxingganshi decocotion.

RESULTS:

Maxingganshi decocotion and its different compatibilities had good effects of prevention and cure the SIRS-ALI. The mechanism maybe concerned with the Maxingganshi decocotion can decrease the TNF-alpha and increase the IL-10. The experiments results also indicated that the action of the full formula was the best. The principal drug was the most important in the formula.

CONCLUSION:

Maxingganshitang has a good effect in anti the ALI; the results indicat that the principal drug is the predominant therapeutic action in the formula ministerial drug. Adjuvant drug and messenger drug can strengthen pharmacodynamic action.

• Authors: Wei-guang Wang, Xu-guang Shi, Li-xiang Zhai, Pei-jian Wang, Xiu-feng Peng, Yu-ying Xu
• Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (Zhong Yao Cai) Vol. 30 Issue 8 Pg. 984-9 (Aug 2007) ISSN: 1001-4454 [Print] China
• PMID: 18074852 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Combinations
• Drugs, Chinese Herbal
• Tumor Necrosis Factor-alpha
• maxingganshi
• Interleukin-10

Topics

• Acute Disease
• Animals
• Capillary Permeability (drug effects)
• Disease Models, Animal
• Drug Combinations
• Drugs, Chinese Herbal (chemistry, pharmacology, therapeutic use)
• Female
• Interleukin-10 (blood)
• Lung Diseases (blood, drug therapy, pathology)
• Male
• Plants, Medicinal (chemistry)
• Pulmonary Edema (blood, drug therapy, pathology)
• Rats
• Rats, Sprague-Dawley
• Systemic Inflammatory Response Syndrome (blood, drug therapy, pathology)
• Tumor Necrosis Factor-alpha (blood)