[The role of cytokines in the seizure activity development in the brain].

Abstract

In this review, the role of pro-inflammatory cytokines, interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha), and anti-inflammatory cytokine, IL-10, in the seizure activity development is analyzed. In recent years, there has been increasing evidence that the transformation of normal pattern of neuronal activity to paroxysmal one is associated with the increased production of these cytokines in the brain. However, the present results indicate that expressions of IL-1, TNF-alpha and IL-10 in the brain are associated with cell injury rather than with seizures per se. These findings suggest that, in response to seizures, these cytokines cause both neuroprotective or neurodegenerative effects and, as a consequence of these effects, the further facilitation or depression of seizure activity.

• Authors: O V Godukhin
• Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova (Zh Vyssh Nerv Deiat Im I P Pavlova) 2007 Sep-Oct Vol. 57 Issue 5 Pg. 541-52 ISSN: 0044-4677 [Print] Russia (Federation)
• PMID: 18064892 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Interleukin-1
• Tumor Necrosis Factor-alpha
• Interleukin-10

Topics

• Animals
• Brain (metabolism, pathology, physiopathology)
• Cell Death
• Humans
• Interleukin-1 (physiology)
• Interleukin-10 (physiology)
• Neurons (pathology)
• Seizures (metabolism, pathology, physiopathology)
• Tumor Necrosis Factor-alpha (physiology)