EBV-1 and HCMV in aggressive periodontitis in Brazilian patients.
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| Abstract |
The purpose of the present investigation was to compare the presence of Epstein-Barr virus type 1 (EBV-1) and of Human Cytomegalovirus (HCMV) in crevicular fluid samples from deep and shallow periodontal pocket sites of Brazilian patients with aggressive periodontitis. A total of 30 systemically healthy patients with aggressive periodontitis participated in the study. Paper points were inserted into 2 gingivitis sites (<3 mm) and into 2 periodontitis sites (>5 mm) in each patient. PCR assay was used to identify genomic copies of HCMV and EBV-1. Twenty-three patients (77%) were positive for EBV-1, while only 2 patients (6%) were positive for HCMV. The McNemar test revealed a positive association between EBV-1 and periodontal lesions (p=0.043). Thirty-four (57%) out of 60 periodontitis sites were positive for EBV-1, whereas 18 (30%) gingivitis sites were positive (p=0.01). Only two sites (6.7%) were positive for HCMV. No positive association was found between HCMV and periodontitis or gingivitis (p=0.479). The elevated occurrence of EBV-1 DNA in periodontal pockets of patients with aggressive periodontitis supports a possible periodontopathic role of this virus.
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| Authors | Soraia Almeida Watanabe, Jeane de Fátima Correia-Silva, Martinho Campolina Rebello Horta, José Eustáquio da Costa, Ricardo Santiago Gomez |
| Journal | Brazilian oral research (Braz Oral Res) 2007 Oct-Dec Vol. 21 Issue 4 Pg. 336-41 ISSN: 1806-8324 [Print] Brazil |
| PMID | 18060261 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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