Reduced anti-PRP antibody response to Hib immunisation in preterm (<32 weeks) UK infants who received inactivated polio (eIPV).

Abstract

A vaccine containing inactivated polio (eIPV) (Pediacel) is now used in the UK. The effect of the eIPV on other components is not well understood. We studied Haemophilus influenzae type b (Hib) and tetanus responses in preterm infants, <32 weeks gestation at birth, immunised with the (then) standard UK primary vaccines and either oral polio vaccine (OPV) or eIPV and analysed the effect showing reduced Hib responses with eIPV.

• Authors: Janet E Berrington, Alan C Fenton, Andrew J Cant, Gavin P Spickett, Marilyn O'Keeffe, John N S Matthews
• Journal: Vaccine (Vaccine) Vol. 25 Issue 49 Pg. 8206-8 (Nov 28 2007) ISSN: 0264-410X [Print] Netherlands
• PMID: 17977631 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antibodies, Bacterial
• Diphtheria-Tetanus-acellular Pertussis Vaccines
• Haemophilus Vaccines
• Poliovirus Vaccine, Inactivated
• Poliovirus Vaccine, Oral
• Polysaccharides
• Tetanus Toxoid
• Vaccines, Combined
• polyribitol phosphate

Topics

• Antibodies, Bacterial (blood)
• Diphtheria-Tetanus-acellular Pertussis Vaccines (administration & dosage, immunology)
• Haemophilus Infections (prevention & control)
• Haemophilus Vaccines (administration & dosage, immunology)
• Haemophilus influenzae type b (immunology)
• Humans
• Immunization
• Infant
• Infant, Low Birth Weight
• Infant, Newborn
• Infant, Premature
• Infant, Very Low Birth Weight
• Poliovirus Vaccine, Inactivated (administration & dosage)
• Poliovirus Vaccine, Oral (administration & dosage)
• Polysaccharides (immunology)
• Tetanus Toxoid (immunology)
• United Kingdom
• Vaccines, Combined