Seroprevalence and genital DNA prevalence of HPV types 6, 11, 16 and 18 in a cohort of young Norwegian women: study design and cohort characteristics.

Abstract

BACKGROUND:

Long-term efficacy evaluations of a quadrivalent HPV type 6/11/16/18 vaccine are ongoing in the Nordic region. As there are limited epidemiological data on HPV infection in Norway, we determined prevalence and identified sociobehavioural correlates of HPV 6/11/16/18 infection in young Norwegian women.

METHODS:

Norwegian (n=898) women, aged 1624 years, were enrolled in a 4-year prospective study. At enrolment and at 6-month intervals thereafter, an interview on behavioural data and a gynaecological examination were undertaken. Genital samples were tested for the L1,E6 and E7 genes of HPV-6/11/16/18, and serum anti-HPV-6/11/16/18 levels were measured using a competitive Luminex immunoassay (cLIA). Results. DNA and seroprevalence of HPV 6, 11, 16 or 18 ranged from 0.9 to 16.3% and 2.6 to 16.2%,respectively; and most infected women (approximately 75%) were infected with only 1 type. Of the HPV DNA positive cases, 54.3, 50.0,47.3 and 38.5% had detectable HPV 6, 11, 16 or 18 antibodies, respectively. More than 50% of the high-grade cervical intraepithelial neoplasia (CIN) cases were HPV-16 or HPV-18 DNA positive. Lifetime number of partners was the strongest and only predictor of sero- and DNA-positivity across the 4 HPV types.

CONCLUSION:

Given the high prevalence of HPV infection among young women with mostly single-type infection, and the fact that type-specific HPV screening is not recommended prior to the administration of the quadrivalent HPV vaccine, our data suggest the importance of widespread,rather than targeted, immunisation.

• Authors: Finn Egil Skjeldestad, Vinay Mehta, Heather L Sings, Torbjørn Øvreness, Jennifer Turpin, Ling Su, Patricia Boerckel, Christine Roberts, Janine Bryan, Kathrin U Jansen, Mark T Esser, Kai-Li Liaw
• Journal: Acta obstetricia et gynecologica Scandinavica (Acta Obstet Gynecol Scand) Vol. 87 Issue 1 Pg. 81-8 ( 2008) ISSN: 1600-0412 [Electronic] United States
• PMID: 17943470 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Viral
• DNA, Viral

Topics

• Adolescent
• Adult
• Alphapapillomavirus (genetics, isolation & purification)
• Antibodies, Viral (blood)
• Cohort Studies
• DNA, Viral (analysis, genetics)
• Female
• Humans
• Norway (epidemiology)
• Papillomavirus Infections (epidemiology, virology)
• Polymerase Chain Reaction
• Prospective Studies
• Seroepidemiologic Studies
• Sexual Behavior
• Uterine Cervical Neoplasms (epidemiology, virology)