Abstract | BACKGROUND: OBJECTIVE: DESIGN: Randomized, double-blind, controlled trial. SETTING: Copenhagen Trauma Center, Copenhagen, Denmark. PATIENTS: 212 consecutive adult trauma patients admitted between July 2003 and August 2005. Eligible patients needed a urinary catheter on arrival and were excluded if they were HIV positive, were pregnant, had a primary burn injury, or were receiving steroid treatment or if informed consent was unattainable. INTERVENTIONS: MEASUREMENTS:
Catheter-associated bacteriuria and funguria, defined as at least 10(3) colony-forming units/mL, was assessed daily until removal of the catheter, with a prespecified minimum of 24-hour follow-up for the primary analysis. The microbiologist was blinded to study group assignment. RESULTS: LIMITATIONS: The clinical significance of asymptomatic bacteriuria and funguria is unclear. Data were missing in 27% of patients, and the magnitude of effect of the nitrofurazone catheters varied by assumptions about outcomes in patients who did not complete 24-hour follow-up. CONCLUSIONS:
Nitrofurazone-impregnated urinary catheters reduced the incidence of CABF in adult trauma patients, reducing the need to change or prescribe new antimicrobial therapy. ClinicalTrials.gov registration number: NCT00192985.
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Authors | Jakob Stensballe, Michael Tvede, Dagnia Looms, Freddy Knudsen Lippert, Benny Dahl, Else Tønnesen, Lars Simon Rasmussen |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 147
Issue 5
Pg. 285-93
(Sep 04 2007)
ISSN: 1539-3704 [Electronic] United States |
PMID | 17785483
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents, Urinary
- Nitrofurazone
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Topics |
- Adult
- Anti-Infective Agents, Urinary
(administration & dosage)
- Bacterial Infections
(prevention & control)
- Catheters, Indwelling
(adverse effects)
- Double-Blind Method
- Female
- Humans
- Male
- Mycoses
(prevention & control)
- Nitrofurazone
(administration & dosage)
- Urinary Catheterization
(adverse effects)
- Urinary Tract Infections
(prevention & control)
- Wounds and Injuries
(therapy)
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