No evidence for an association between G protein beta3 subunit gene C825T polymorphism and tardive dyskinesia in schizophrenia.

Abstract

OBJECTIVE:

Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. We evaluated candidate functional polymorphism of the G protein beta3 subunit (GNB3) gene for association with drug-induced TD in the Korean schizophrenic patients.

METHODS:

We investigated whether the C825T polymorphism of the GNB3 gene is associated with the TD in a Korean sample of schizophrenic patients with (n = 83) and without TD (n = 126), matched for antipsychotic drug exposure and other relevant variables.

RESULTS:

The distribution of genotypes and allele frequencies of GNB3 were not different between schizophrenic patients with TD and without TD (p > 0.05).

CONCLUSION:

Within the limitations imposed by the size of the clinical sample, these findings suggest that the GNB3 825 C/T single nucleotide polymorphism (SNP) does not contribute significantly to risk for TD.

• Authors: Heon-Jeong Lee, Seung-Gul Kang, Jong-Woo Paik, Moon-Soo Lee, Bang-Hyun Cho, Young-Min Park, Won Kim, Jung-Eun Choi, In-Kwa Jung, Leen Kim, Min-Soo Lee
• Journal: Human psychopharmacology (Hum Psychopharmacol) Vol. 22 Issue 8 Pg. 501-4 (Dec 2007) ISSN: 0885-6222 [Print] England
• PMID: 17726725 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antipsychotic Agents
• G-protein beta3 subunit
• Heterotrimeric GTP-Binding Proteins

Topics

• Adult
• Antipsychotic Agents (adverse effects, therapeutic use)
• Dyskinesia, Drug-Induced (genetics)
• Exons (genetics)
• Female
• Gene Frequency
• Genotype
• Heterotrimeric GTP-Binding Proteins (genetics)
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide (genetics)
• Schizophrenia (drug therapy, genetics)