Abstract | PURPOSE: METHODS: pMCAO was produced by surgical insertion of a silicone-coated nylon filament into the right internal carotid artery. Laser-Doppler flowmetry was used to monitor cerebral blood flow for 10 min post-occlusion. PROG (8 mg/kg) or vehicle (2-hydroxypropyl-beta-cyclodextrin) was administered intraperitoneally at 1 h post-occlusion followed by subcutaneous injections at 6, 24 and 48 h post-occlusion. Measurements of infarct volumes (cortical, subcortical and total) were performed at 72 h and functional recovery, assessed by rotarod test, were performed 24, 48, and 72 h after pMCAO. RESULTS: Following PROG treatment, stained sections revealed a significant reduction in cortical, caudate-putamen and hemispheric infarct volumes (% contralateral structure) compared to vehicle-injected controls. In addition, PROG treatment reduced functional deficits on the accelerating rotarod apparatus. CONCLUSION:
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Authors | Iqbal Sayeed, Bushra Wali, Donald G Stein |
Journal | Restorative neurology and neuroscience
(Restor Neurol Neurosci)
Vol. 25
Issue 2
Pg. 151-9
( 2007)
ISSN: 0922-6028 [Print] Netherlands |
PMID | 17726274
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Neuroprotective Agents
- Progesterone
|
Topics |
- Animals
- Brain
(drug effects, pathology)
- Brain Ischemia
(etiology, pathology)
- Cerebral Infarction
(pathology)
- Infarction, Middle Cerebral Artery
(complications, physiopathology)
- Male
- Motor Activity
(drug effects)
- Neuroprotective Agents
(pharmacology)
- Progesterone
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Time Factors
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