Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms.

Abstract

Ginger has been used throughout the world as spice, food and traditional herb. We found that 6-gingerol, a phenolic alkanone isolated from ginger, enhanced the TRAIL-induced viability reduction of gastric cancer cells while 6-gingerol alone affected viability only slightly. 6-Gingerol facilitated TRAIL-induced apoptosis by increasing TRAIL-induced caspase-3/7 activation. 6-Gingerol was shown to down-regulate the expression of cIAP1, which suppresses caspase-3/7 activity, by inhibiting TRAIL-induced NF-kappaB activation. As 6-shogaol has a chemical structure similar to 6-gingerol, we also assessed the effect of 6-shogaol on the viability of gastric cancer cells. Unlike 6-gingerol, 6-shogaol alone reduced the viability of gastric cancer cells. 6-Shogaol was shown to damage microtubules and induce mitotic arrest. These findings indicate for the first time that in gastric cancer cells, 6-gingerol enhances TRAIL-induced viability reduction by inhibiting TRAIL-induced NF-kappaB activation while 6-shogaol alone reduces viability by damaging microtubules.

• Authors: Kazuhiro Ishiguro, Takafumi Ando, Osamu Maeda, Naoki Ohmiya, Yasumasa Niwa, Kenji Kadomatsu, Hidemi Goto
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 362 Issue 1 Pg. 218-223 (Oct 12 2007) ISSN: 0006-291X [Print] United States
• PMID: 17706603 (Publication Type: Journal Article)

Chemical References

• Catechols
• Fatty Alcohols
• NF-kappa B
• Plant Extracts
• TNF-Related Apoptosis-Inducing Ligand
• shogaol
• gingerol
• Caspase 3
• Caspase 7

Topics

• Animals
• Caspase 3 (metabolism)
• Caspase 7 (metabolism)
• Catechols (pharmacology)
• Cell Line, Tumor
• Cell Survival
• Fatty Alcohols (pharmacology)
• Zingiber officinale (metabolism)
• Humans
• Mice
• Mice, Nude
• Microtubules (metabolism)
• NF-kappa B (metabolism)
• Plant Extracts (pharmacology)
• Stomach Neoplasms (metabolism, pathology)
• TNF-Related Apoptosis-Inducing Ligand (metabolism)