Abstract | BACKGROUND: Several clinical studies have suggested possible increase in cardiovascular risk during and in the first weeks after an acute inflammatory disease. Using influenza vaccine as inflammatory stimulus, we investigated whether arterial endothelial dysfunction could persist beyond the inflammatory state, and whether amplified oxidative modification of low-density lipoprotein ( LDL) accompanies this vascular disturbance. METHODS AND SUBJECTS: RESULTS:
Influenza vaccination caused a slight elevation in CRP (from 0.5+/-0.1 at baseline, to 2+/-0.6 mg/L, P = 0.01) and fibrinogen (from 2.3+/-0.1 to 2.7+/-0.1 g/L, P = 0.01) at 2 days, which completely resolved at 14 days (CRP: 0.6+/-0.2 mg/L, P = 0.9, and fibrinogen: 2.3+/-0.1 g/L, P = 0.8 versus baseline). OxLDL antibody levels rose significantly at 2 days (from 1+/-0.1 at baseline to 2+/-0.4, P = 0.04), and remained elevated at 14 days (1.7+/-0.3, P = 0.1 versus baseline). FMD of the brachial artery decreased at 2 days (from 8.3+/-1.2% at baseline, to 5.4+/-1%, P = 0.05) with a further decrease at 14 days (4.9+/-0.8%, P = 0.03 versus baseline). The dilatory responses to GTN and the carotid IMT remained unchanged throughout the study period (P>0.5). CONCLUSION: Abnormalities in arterial function and LDL oxidation may persist for at least 2 weeks after a slight inflammatory reaction induced by influenza vaccination. These could explain in part the earlier reported increase in cardiovascular risk during the first weeks after an acute inflammatory disorder.
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Authors | Petru Liuba, Elhadi H Aburawi, Erkki Pesonen, Sture Andersson, Lennart Truedsson, Seppo Ylä-Herttuala, Lars Holmberg |
Journal | Annals of medicine
(Ann Med)
Vol. 39
Issue 5
Pg. 392-9
( 2007)
ISSN: 0785-3890 [Print] England |
PMID | 17701480
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Cholesterol, HDL
- Influenza Vaccines
- Lipoproteins, LDL
- Vasodilator Agents
- oxidized low density lipoprotein
- Fibrinogen
- C-Reactive Protein
- Nitroglycerin
- Cyclic GMP
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Topics |
- Adolescent
- Adult
- Biomarkers
(blood)
- Brachial Artery
(diagnostic imaging, drug effects, physiology)
- C-Reactive Protein
(analysis)
- Carotid Artery, Common
(diagnostic imaging)
- Cholesterol, HDL
(blood)
- Cyclic GMP
(blood)
- Endothelium, Vascular
(diagnostic imaging, drug effects)
- Fibrinogen
(analysis)
- Follow-Up Studies
- Humans
- Hyperemia
(diagnostic imaging, physiopathology)
- Inflammation
(blood, complications)
- Influenza Vaccines
(adverse effects)
- Lipoproteins, LDL
(blood, chemistry)
- Male
- Nitroglycerin
(pharmacology)
- Research Design
- Ultrasonography
- Vasodilation
(physiology)
- Vasodilator Agents
(pharmacology)
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