Abstract | BACKGROUND: Intensive efforts are being made to develop new approaches for adjuvant or neoadjuvant treatment in pancreas carcinoma. Recently, we established an animal model simulating an adjuvant therapeutic treatment setting. In order to additionally mimic a neoadjuvant treatment regime, we further developed the preclinical testing system. METHODS: RESULTS: 28 of 32 animals survived the treatment setting. The largest pancreatic tumor masses were seen in animals without any chemotherapy, and the different chemotherapy protocols resulted in a stepwise reduction of the tumor mass. The mean weight of locally recurrent tumors was 553.1 +/- 133.2 mg (control) and 44 +/- 21.8 mg (adjuvant treatment group). Animals in the neoadjuvant treatment group developed larger tumor masses (215 +/- 191.3 mg) but fewer organ metastases. An extended neoadjuvant treatment setting proved to be most effective, resulting in the smallest tumor masses (25.6 +/- 8.8 mg) and the fewest organ metastases. CONCLUSION: Murine orthotopic tumor resection is an excellent simulation of the clinical situation and therefore provides a relevant option for preclinical comparative testing of new therapeutic strategies. To our knowledge, this is the first model described, in which all different therapeutic regimes for pancreatic carcinoma were systematically compared with each other in a standardized manner. The extended neoadjuvant regime proved to be superior.
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Authors | Jan-Hendrik Egberts, Bodo Schniewind, Bence Sipos, Sebastian Hinz, Holger Kalthoff, Jürgen Tepel |
Journal | Cancer biology & therapy
(Cancer Biol Ther)
Vol. 6
Issue 8
Pg. 1227-32
(Aug 2007)
ISSN: 1555-8576 [Electronic] United States |
PMID | 17700058
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimetabolites, Antineoplastic
- Deoxycytidine
- Gemcitabine
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Topics |
- Animals
- Antimetabolites, Antineoplastic
(therapeutic use)
- Deoxycytidine
(analogs & derivatives, therapeutic use)
- Disease Models, Animal
- Mice
- Mice, SCID
- Neoadjuvant Therapy
(methods)
- Neoplasm Transplantation
- Pancreatectomy
- Pancreatic Neoplasms
(drug therapy, pathology, surgery)
- Transplantation, Heterologous
- Gemcitabine
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