Abstract | PURPOSE: METHODS: This multicenter study was conducted in randomized, double-masked fashion with a parallel active control group. Patients undergoing phacoemulsification surgery with IOL implantation were assigned to one of two treatment groups receiving study drug in addition to standard therapy. Study drug was administered four times daily beginning one day before surgery, postoperatively for 14 days, then twice daily until the bottle was empty. Clinical efficacy was compared for differences in corneal surface keratitis, anterior chamber cells and flare, and postoperative pain. Results were compared on day 1, 2 weeks, and 4 weeks postoperatively. RESULTS: No statistical differences in clinical efficacy or safety were seen between the two formulations tested at any time point evaluated. CONCLUSIONS:
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Authors | Michael B Raizman, Eric D Donnenfeld, Arthur J Weinstein |
Journal | Current medical research and opinion
(Curr Med Res Opin)
Vol. 23
Issue 10
Pg. 2325-31
(Oct 2007)
ISSN: 1473-4877 [Electronic] England |
PMID | 17697456
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- prednisolone acetate
- Prednisolone
|
Topics |
- Administration, Topical
- Anti-Inflammatory Agents
(administration & dosage, therapeutic use)
- Cataract Extraction
(adverse effects)
- Chemistry, Pharmaceutical
- Double-Blind Method
- Humans
- Inflammation
(etiology, prevention & control)
- Lens Implantation, Intraocular
- Pain, Postoperative
(drug therapy)
- Prednisolone
(administration & dosage, analogs & derivatives, therapeutic use)
- Treatment Outcome
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