Circulating advanced glycation end products (AGEs) and soluble form of receptor for AGEs (sRAGE) are independent determinants of serum monocyte chemoattractant protein-1 (MCP-1) levels in patients with type 2 diabetes.

Abstract

BACKGROUND:

Atherosclerosis is an inflammatory disease. Monocyte chemoattractant protein-1 (MCP-1) is an essential chemokine responsible for the recruitment of monocytes to inflammatory lesions in the vasculature, an initial step of atherosclerosis. Since serum levels of MCP-1 are higher in patients with type 2 diabetes, inhibition of MCP-1 may be a novel therapeutic target for prevention of accelerated atherosclerosis in diabetes. However, little is known about the regulation and determinants of serum MCP-1 levels in patients with diabetes. In this study, we examined the determinants of serum MCP-1 levels in type 2 diabetic patients.

METHODS:

Eighty-six consecutive outpatients with type 2 diabetes (36 male and 50 female; mean age 68.4+/-9.6) underwent a complete history and physical examination, determination of blood chemistries, MCP-1, tumour necrosis factor-alpha, adiponectin, advanced glycation end products (AGEs), and soluble form of receptor for AGEs (sRAGE). We examined the association between MCP-1 levels and those in anthropometric, metabolic and inflammatory variables in these subjects.

RESULTS:

Univariate regression analysis showed that serum levels of MCP-1 were positively associated with AGEs (r=0.386, p<0.001) and sRAGE (r=0.315, p<0.001). After adjusting for age and sex, AGEs (p<0.001) and sRAGE (p<0.05) still remained significant.

CONCLUSION:

The results demonstrate for the first time that circulating levels of AGEs and sRAGE are independent determinants of serum MCP-1 levels in patients with type 2 diabetes. Our present observations suggest the AGEs-RAGE system may be mainly involved in the elevation of MCP-1 in type 2 diabetic patients.

• Authors: Kazuo Nakamura, Sho-ichi Yamagishi, Hisashi Adachi, Takanori Matsui, Yayoi Kurita-Nakamura, Masayoshi Takeuchi, Hiroyoshi Inoue, Tsutomu Imaizumi
• Journal: Diabetes/metabolism research and reviews (Diabetes Metab Res Rev) Vol. 24 Issue 2 Pg. 109-14 (Feb 2008) ISSN: 1520-7552 [Print] England
• PMID: 17694504 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright (c) 2007 John Wiley & Sons, Ltd.

Chemical References

• CCL2 protein, human
• Chemokine CCL2
• Glycation End Products, Advanced
• Receptor for Advanced Glycation End Products
• Receptors, Immunologic

Topics

• Aged
• Chemokine CCL2 (blood)
• Diabetes Mellitus, Type 2 (blood)
• Female
• Glycation End Products, Advanced (blood)
• Humans
• Male
• Middle Aged
• Receptor for Advanced Glycation End Products
• Receptors, Immunologic (blood)
• Regression Analysis
• Solubility