Assessment of anti-inflammatory and antinociceptive activities of Daphne pontica L. (Thymelaeaceae).

Abstract

The n-hexane, diethylether, ethyl acetate and methanol extracts from roots, leaves, stems and flowers with young leaves of Daphne pontica L. (Thymelaeaceae) were investigated for their in vivo anti-inflammatory and antinociceptive activities. For the anti-inflammatory activity assessment, carrageenan-induced hind paw edema, PGE(2)-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models and for the antinociceptive activity, p-benzoquinone-induced abdominal constriction test were used. Only ethyl acetate extracts of the roots showed significant anti-inflammatory activity on carrageenan-induced (22.7-32.0% inhibition) and PGE(2)-induced hind paw edema (3.2-27.3% inhibition) as well as 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema (47.8-43.3% inhibition) models at 50 mg/kg dose without inducing any apparent gastric lesion or acute toxicity, whereas the other extracts were shown to be ineffective. In addition to roots, ethyl acetate extracts of the stems exhibited 19.5-29.9%; 5.3-23.9%; 36.6-28.1% inhibition on carrageenan-induced and PGE(2)-induced hind paw edema as well as 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models, respectively. On the other hand, none of the extracts showed any significant antinociceptive activity.

• Authors: Esra Kupeli, Alev Tosun, Erdem Yesilada
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 113 Issue 2 Pg. 332-7 (Sep 05 2007) ISSN: 0378-8741 [Print] Ireland
• PMID: 17681445 (Publication Type: Journal Article)

Chemical References

• Acetates
• Analgesics
• Anti-Inflammatory Agents
• Benzoquinones
• Plant Extracts
• quinone
• ethyl acetate
• Carrageenan
• Dinoprostone
• Tetradecanoylphorbol Acetate
• Aspirin
• Methanol

Topics

• Acetates (chemistry)
• Analgesics (isolation & purification, pharmacology)
• Animals
• Anti-Inflammatory Agents (isolation & purification, pharmacology)
• Aspirin (toxicity)
• Benzoquinones (toxicity)
• Carrageenan (toxicity)
• Colic (chemically induced, prevention & control)
• Daphne (chemistry)
• Dinoprostone (toxicity)
• Ear, External (drug effects, pathology)
• Edema (chemically induced, prevention & control)
• Flowers (chemistry)
• Hindlimb
• Male
• Medicine, Traditional
• Methanol (chemistry)
• Mice
• Plant Extracts (chemistry, isolation & purification, pharmacology)
• Plant Leaves (chemistry)
• Plant Roots (chemistry)
• Plant Stems (chemistry)
• Tetradecanoylphorbol Acetate (toxicity)
• Time Factors
• Turkey