Imipramine reverses the depressive symptoms in sepsis survivor rats.

Abstract

OBJECTIVE:

To evaluate the antidepressant effect of imipramine on depressive symptoms observed in sepsis survivors rats.

DESIGN AND SETTING:

Prospective, controlled experiment in an animal basic science laboratory.

SUBJECTS:

Male Wistar rats weighing 300-350 g.

INTERVENTIONS:

The rats underwent cecal ligation and perforation (CLP; sepsis group) with "basic support" (saline at 50 ml/kg immediately and 12 h after CLP plus ceftriaxone at 30 mg/kg and clindamycin at 25 mg/kg 6, 12, and 18 h after CLP) or sham-operated (control group). After 10 days of recovery rats received intraperitoneal injections of imipramine 10 mg/kg or saline and were subjected to the forced swimming test.

MEASUREMENTS AND RESULTS:

The observed increase in the immobility time in the forced swimming test in animals subjected to CLP, as a parameter of depressive behavior, was reversed by imipramine.

CONCLUSIONS:

The depressive symptoms evaluated by forced swimming test had been reversed after imipramine administration. Our data provide evidence that CLP-induced depressive symptoms are sensitive to antidepressants.

• Authors: Lisiane Tuon, Clarissa M Comim, Moises M Antunes, Larissa S Constantino, Roberta A Machado, Ivan Izquierdo, João Quevedo, Felipe Dal-Pizzol
• Journal: Intensive care medicine (Intensive Care Med) Vol. 33 Issue 12 Pg. 2165-7 (Dec 2007) ISSN: 0342-4642 [Print] United States
• PMID: 17668182 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antidepressive Agents, Tricyclic
• Imipramine

Topics

• Animals
• Antidepressive Agents, Tricyclic (administration & dosage, pharmacology, therapeutic use)
• Brazil
• Depression (drug therapy, physiopathology)
• Imipramine (administration & dosage, pharmacology, therapeutic use)
• Prospective Studies
• Rats
• Sepsis (psychology)
• Treatment Outcome