Paraganglioma: report of a rare case with ovarian involvement.

Abstract

We report a well-documented case of paraganglioma involving right ovary, which was initially misdiagnosed as a Sertoli-Leydig cell tumor and recurred one year later. The right ovarian tumor measured 105x90x60 mm and was associated to a subdiaphragmatic tumor measuring 80x60x35 mm, a peritoneal and a preureteral nodules measuring 10 mm either. Microscopically, tumor cells were arranged in trabeculae and cords separated by a delicate stroma. Their cytoplasm was abundant granular and eosinophilic. Their nuclei were enlarged and regular in size with coarse chromatine and a large nucleolus. The tumor expressed neuroendocrine markers (chromogranin, synaptophysin) epithelial membrane antigen and focally cytokeratin 7 and E-cadherin. Pathological ovarian paraganglioma diagnosis could be difficult but one should be aware of its bona fide existence. The clinical course is favourable in most of the cases.

• Authors: D Bacha, K Mrad, R Dhouib, M Driss, I Abbes, S Sassi, K Ben Romdhane
• Journal: Pathologica (Pathologica) Vol. 99 Issue 2 Pg. 50-3 (Apr 2007) ISSN: 0031-2983 [Print] Italy
• PMID: 17633808 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Female
• Humans
• Ovarian Neoplasms (pathology)
• Paraganglioma (pathology)