Diffuse large B-cell lymphoma in hyperimmunoglobulinemia E syndrome.

Abstract

We report a case of diffuse large B-cell lymphoma occurring in a patient with the hyperimmunoglobulinemia E syndrome, a rare immune disorder defined by elevated immunoglobulin E levels and recurrent bacterial and fungal infections often manifesting as cold abscesses. This case further supports the notion that patients with hyperimmunoglobulinemia E have an increased risk of lymphoid malignancies and should be closely monitored. Despite a theoretic risk of severe infectious complications, chemotherapy was well tolerated and resulted in a sustained complete remission.

• Authors: Nadège Wallet, David Ghez, Richard Delarue, Felipe Suarez, Marie-Thérèse Rubio, Alain Fischer, Danielle Canioni, Bruno Varet, Olivier Hermine
• Journal: Clinical lymphoma & myeloma (Clin Lymphoma Myeloma) Vol. 7 Issue 6 Pg. 425-7 (May 2007) ISSN: 1557-9190 [Print] United States
• PMID: 17621409 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Murine-Derived
• Immunoglobulin E
• Rituximab
• Vincristine
• Doxorubicin
• Cyclophosphamide

Topics

• Adolescent
• Antibodies, Monoclonal (therapeutic use)
• Antibodies, Monoclonal, Murine-Derived
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cyclophosphamide (therapeutic use)
• Doxorubicin (therapeutic use)
• Humans
• Immunoglobulin E (blood)
• Job Syndrome (complications)
• Lymphoma, Large B-Cell, Diffuse (complications, drug therapy, pathology)
• Male
• Rituximab
• Treatment Outcome
• Vincristine (therapeutic use)