Abstract |
Alzheimer's disease (AD) is characterized by the deposition of senile plaques and neurofibrillary tangles in the brain. The presence of the amyloid-beta (Abeta) peptide in senile plaques seems to play a central role in the neuropathology of AD. Diagnosis of AD involves neuropsychological examinations or magnetic resonance imaging and, to date, a specific diagnostic marker indicating AD has not been found. This study analysed anti-Abeta antibodies from the serum of 153 patients with AD using an enzyme-linked immunosorbent assay method. The levels of anti-Abeta antibody from patients in the control group (n=193) were compared with those of patients with AD. Our results showed a significantly lower anti-Abeta antibody level in patients with AD than in the control group. These results showed that the anti-Abeta antibody level in serum could potentially be used to diagnose the presence of AD.
|
Authors | M S Song, I Mook-Jung, H J Lee, J Y Min, M H Park |
Journal | The Journal of international medical research
(J Int Med Res)
2007 May-Jun
Vol. 35
Issue 3
Pg. 301-6
ISSN: 0300-0605 [Print] England |
PMID | 17593857
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Amyloid beta-Peptides
- Antibodies
|
Topics |
- Aged
- Alzheimer Disease
(diagnosis, immunology)
- Amyloid beta-Peptides
(immunology)
- Antibodies
(blood)
- Case-Control Studies
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Korea
- Logistic Models
- Male
- Predictive Value of Tests
- Random Allocation
|