[Study of the effectiveness of artificial oxygen carrier on the hemoglobin base in blood loss replacement in dogs].

Abstract

The effectiveness of modified polyhemoglobin proposed as an artificial oxygen carrier (AOC) was evaluated in experiments on dogs with acute fatal hemorrhage. It was shown that total oxygen consumption, arterial blood pressure and circulating blood volume were maintained at the normal physiological levels during 4 h after infusion of 10% solution of polyhemoglobin. AOC infusion provided 100% survival of the animals. It has been concluded that hemoglobin polymer modified with pyridoxal-5'-phosphate can be used as the basis for the production of the medicinal form of AOC.

• Authors: Iu A Litvinenko, I R Kolonina, A V Sokolov, N A Gorbunova
• Journal: Gematologiia i transfuziologiia (Gematol Transfuziol) Vol. 36 Issue 8 Pg. 16-8 (Aug 1991) ISSN: 0234-5730 [Print] Russia (Federation)
• Vernacular Title: Izuchenie éffektivnosti iskusstvennogo perenoschika kisloroda na osnove gemoglobina pri zameshchenii krovopoteri u sobak.
• PMID: 1752403 (Publication Type: English Abstract, Journal Article)

Chemical References

• Blood Substitutes
• Drug Carriers
• Hemoglobins
• Pyridoxal Phosphate
• Oxygen

Topics

• Acute Disease
• Animals
• Blood Substitutes (administration & dosage)
• Bloodletting
• Disease Models, Animal
• Dogs
• Drug Carriers
• Hemoglobins (physiology)
• Hemorrhage (blood, drug therapy, etiology)
• Oxygen (administration & dosage, blood)
• Pyridoxal Phosphate (blood, pharmacology)