Lack of susceptibility to ischemic necrosis of the remnant liver following partial hepatectomy in the rat.

Abstract

BACKGROUND/AIMS:

The increase in liver lobule dimensions that occurs following partial hepatectomy could predispose living related donors to ischemic hepatic injury were shock-like states to occur in the future.

METHODOLOGY:

In the present study, rats that had undergone 70% partial hepatectomies or sham surgery six weeks earlier were progressively bled to a maximum of 40% total circulating blood volume.

RESULTS:

Despite significant increases in liver lobule dimensions (1.5x controls), hepatectomized rats did not manifest biochemical or histologic evidence of early or more extensive hepatic injury when compared to sham-operated controls.

CONCLUSIONS:

The results of this study suggest that despite theoretical concerns, living related donors are not predisposed to develop ischemic hepatic injury were shock-like states to develop in the future.

• Authors: K Watt, K Kives, I Corbin, M Zhang, G Y Minuk
• Journal: Hepato-gastroenterology (Hepatogastroenterology) Vol. 54 Issue 74 Pg. 463-5 (Mar 2007) ISSN: 0172-6390 [Print] Greece
• PMID: 17523299 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Animals
• Hepatectomy
• Ischemia (pathology)
• Liver (blood supply, pathology)
• Liver Regeneration (physiology)
• Liver Transplantation (pathology)
• Living Donors
• Necrosis
• Rats
• Rats, Sprague-Dawley
• Shock (pathology)
• Tissue and Organ Harvesting