Abstract | CONTEXT: OBJECTIVE: DESIGN AND SETTING: We conducted a cross-sectional study at a clinical research center. STUDY PARTICIPANTS: Subjects included 181 women: 140 women with AN [85 not receiving OCPs (AN-E) and 55 receiving OCPs (AN+E)] and 41 healthy controls [28 not receiving OCPs (HC-E) and 13 receiving OCPs (HC+E)]. MAIN OUTCOME MEASURES: RESULTS: Despite low weight, more than 20% of AN+E had high-risk hsCRP levels. AN+E had higher hsCRP than AN-E. AN-E had lower mean hsCRP levels than healthy controls (HC+E and HC-E). IL-6 levels were higher in AN+E with elevated hsCRP (>3 mg/liter) than in AN+E with normal hsCRP levels. IGF-I was inversely associated with hsCRP in healthy women, suggesting a protective effect of GH on CV risk. However, this was not seen in AN. Few patients in any group had high-risk LDL or HDL levels. CONCLUSIONS: Although hsCRP levels are lower in AN than healthy controls, OCP use puts such women at a greater than 20% chance of having hsCRP in the high-CV-risk (>3 mg/liter) category. The elevated mean IL-6 in women with AN and high-risk hsCRP levels suggests that increased systemic inflammation may underlie the hsCRP elevation in these patients. Although OCP use in AN was associated with slightly lower mean LDL and higher mean HDL, means were within the normal range, and few patients in any group had high-risk LDL or HDL levels. IGF-I levels appear to be important determinants of hsCRP in healthy young women. In contrast, IGF-I does not appear to mediate hsCRP levels in AN.
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Authors | Elizabeth A Lawson, Karen K Miller, Vani A Mathur, Madhusmita Misra, Erinne Meenaghan, David B Herzog, Anne Klibanski |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 92
Issue 8
Pg. 3089-94
(Aug 2007)
ISSN: 0021-972X [Print] United States |
PMID | 17519306
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Biomarkers
- Contraceptives, Oral, Hormonal
- Hormones
- Interleukin-6
- Lipoproteins, HDL
- Lipoproteins, LDL
- Insulin-Like Growth Factor I
- C-Reactive Protein
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Topics |
- Adult
- Anorexia Nervosa
(blood)
- Biomarkers
- Body Composition
(physiology)
- Body Weight
(physiology)
- C-Reactive Protein
(metabolism)
- Cardiovascular Diseases
(blood, epidemiology)
- Contraceptives, Oral, Hormonal
(pharmacology)
- Cross-Sectional Studies
- Female
- Hormones
(blood)
- Humans
- Insulin-Like Growth Factor I
(metabolism)
- Interleukin-6
(blood)
- Lipoproteins, HDL
(blood)
- Lipoproteins, LDL
(blood)
- Nutritional Physiological Phenomena
- Risk Factors
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