[Clinical control study of dialysates with different concentrations of calcium on blood pressure in patients under hemodialysis for prolonged period].

Abstract

OBJECTIVE:

To investigate the changes in blood pressure in hemodialysis patients treated with low calcium dialysate or high calcium dialysate for long time.

METHODS:

Fifteen patients undergoing hemodialysis were enrolled in this study. High calcium dialysate (1.75 mmol/L, Dca1.75) was first used for 6 months, then low calcium dialysate (1.25 mmol/L, Dca1.25) was used for 6 months. Serum calcium, phosphate, blood urea nitrogen, and creatinine were measured, blood pressure was recorded before and after hemodialysis at the beginning, and also at 1, 2, 3 and 4 hours after hemodialysis.

RESULTS:

Compared with that before the treatment, systolic and diastolic blood pressure lowered significantly after single low calcium hemodialysis for 4 hours (both P<0.05), while systolic and diastolic blood pressure rose significantly after single high calcium hemodialysis (both P<0.05). Systolic blood pressure changed more obviously after two hemodialyses (both P<0.05). Changes in systolic, diastolic and mean blood pressure were positively related to changes in serum total calcium (r(1)=0.326, P(1)=0.054; r(2)=0.383, P(2)=0.037; r(3)=0.391, P(3)=0.032). During 6 months of hemodialysis with low calcium dialysate, blood pressure lowered slightly with no significant difference in it (P>0.05), while systolic blood pressure rose during 6 months of hemodialysis with high calcium dialysate (P<0.05). Changes in systolic blood pressure were significantly different between two groups using dialysates with different calcium concentrations (P<0.05).

CONCLUSION:

Systolic blood pressure and incidence of hypertension decrease after single low calcium hemodialysis.

• Authors: Cheng Wang, Tan-Qi Lou, Zhu-Jiang Chen, Hua Tang, Cheng-Gang Shi, Xue-Qing Yu, Pei-da Yin
• Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue) Vol. 19 Issue 4 Pg. 236-8 (Apr 2007) ISSN: 1003-0603 [Print] China
• PMID: 17448281 (Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dialysis Solutions
• Calcium

Topics

• Blood Pressure (drug effects, physiology)
• Calcium (administration & dosage, pharmacology)
• Dialysis Solutions (chemistry)
• Female
• Humans
• Hypertension (etiology, prevention & control)
• Male
• Renal Dialysis (adverse effects)