Abstract | OBJECTIVE: METHOD: In this study, we genotyped five markers across the gene on 177 small, nuclear families consisting of an attention deficit hyperactivity disorder proband, their parents, and 43 affected siblings. We examined the transmission of the alleles at each one of these sites and the haplotypes of the polymorphisms using the transmission disequilibrium test. RESULT: Our observations did not yield any evidence of biased transmission of the alleles at any polymorphism or haplotype. On the basis of the evidence for synapsins in learning and memory from animal models, we also investigated the relationship of this gene to verbal short-term and working memory as measured by digit span forward and backwards. No evidence was found for an association of this gene to these traits. CONCLUSION:
|
Authors | Rohit Makkar, Lissette Gomez, Karen G Wigg, Abel Ickowicz, Tejaswee Pathare, Rosemary Tannock, Molly Malone, James L Kennedy, Russell Schachar, Cathy L Barr |
Journal | Psychiatric genetics
(Psychiatr Genet)
Vol. 17
Issue 2
Pg. 109-12
(Apr 2007)
ISSN: 0955-8829 [Print] England |
PMID | 17413450
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- DNA Primers
- Genetic Markers
- Neuropeptides
- Neurotransmitter Agents
- Phosphoproteins
- SYN3 protein, human
- Synapsins
- DNA
|
Topics |
- Attention Deficit Disorder with Hyperactivity
(genetics)
- DNA
(blood, genetics, isolation & purification)
- DNA Primers
- Female
- Genetic Markers
- Genotype
- Humans
- Lymphocytes
(physiology)
- Male
- Neuropeptides
(genetics)
- Neurotransmitter Agents
(metabolism, physiology)
- Nuclear Family
- Phosphoproteins
(genetics)
- Polymorphism, Genetic
- Siblings
- Synapsins
|