Essential role of placental leucine aminopeptidase in gynecologic malignancy.

Abstract

The M1 aminopeptidase family is important for the maturation or degradation of bioactive peptides by hydrolyzing their N-terminal amino acids. Some investigators have studied aminopeptidase in the maintenance of homeostasis including maintenance of normal pregnancy, memory retention, blood pressure regulation and antigen presentation. However, there are a few reports on the relation between the M1 aminopeptidase family and carcinoma. In addition to its capacity to degrade a range of peptides, placental-leucine aminopeptidase (P-LAP) has novel functions that impact on normal cells and neoplastic cells. P-LAP is the focus of this review.

• Authors: Shigehiko Mizutani, Kiyosumi Shibata, Fumitaka Kikkawa, Akira Hattori, Masafumi Tsujimoto, Masakazu Ishii, Hiroshi Kobayashi
• Journal: Expert opinion on therapeutic targets (Expert Opin Ther Targets) Vol. 11 Issue 4 Pg. 453-61 (Apr 2007) ISSN: 1744-7631 [Electronic] England
• PMID: 17373876 (Publication Type: Journal Article, Review)

Chemical References

• Receptors, Oxytocin
• Oxytocin
• Cystinyl Aminopeptidase
• leucyl-cystinyl aminopeptidase

Topics

• Animals
• Cystinyl Aminopeptidase (classification, metabolism)
• Female
• Genital Neoplasms, Female (enzymology, pathology)
• Humans
• Oxytocin (metabolism)
• Receptors, Oxytocin (metabolism)