Abstract |
Hormone replacement therapy (HRT) containing estrogens is generally used to relieve climacteric symptoms and to prevent osteoporosis and coronary heart disease [1], however, there has been increasing evidence of the HRT as the risk of hormone-dependent neoplasms including breast cancer [2], uterine endometrial cancer [3], ovarian cancer [4], and even lung cancer [5]. Noteworthy is mucinous cyst neoplasms (MCNs) of the pancreas, characterized by mucin-producing columnar epithelium supported by "ovarian-like" mesenchymal stroma, occur mostly in females expressing estrogen receptors [6, 7]. Although several reports regarding the closed relationship between MCNs and pregnancy [8, 9] might imply potential sex hormone-dependency of the MCNs [10], no correlation has been reported. This is the first case report of malignant MCN developing during continuous HRT after hysterectomy.
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Authors | Shinji Tanaka, Toru Kawamura, Noriaki Nakamura, Kenichi Teramoto, Shigeki Arii |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 52
Issue 5
Pg. 1326-8
(May 2007)
ISSN: 0163-2116 [Print] United States |
PMID | 17372823
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Receptors, Estrogen
- Receptors, Progesterone
- Inhibins
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Topics |
- Cystadenocarcinoma, Mucinous
(chemically induced, chemistry, pathology, surgery)
- Estrogen Replacement Therapy
(adverse effects)
- Female
- Humans
- Hysterectomy
- Inhibins
(analysis)
- Middle Aged
- Neoplasms, Hormone-Dependent
(chemically induced, chemistry, pathology, surgery)
- Pancreatectomy
- Pancreatic Neoplasms
(chemically induced, chemistry, pathology, surgery)
- Receptors, Estrogen
(analysis)
- Receptors, Progesterone
(analysis)
- Splenectomy
- Stromal Cells
(chemistry, drug effects, pathology)
- Treatment Outcome
- Ultrasonography
(methods)
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