Abstract |
This study examined the neuroprotective effects of kobophenol A (kob A), oligomeric stillbene, and a resveratrol tetramer. Neuronal death induced by the withdrawal of tropic support was ameliorated by kob A. The protective effect of kob A against nitrosative/oxidative or mitochondrial damages resulted in the inhibition of the ROS, intracellular calcium ion level, and mitochondrial transmembrane potential changes on SH-SY5Y cells.
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Authors | Sung Ryul Lee, Jong Hwan Kwak, Hyoung Ja Kim, Suhkneung Pyo |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 17
Issue 7
Pg. 1879-82
(Apr 01 2007)
ISSN: 0960-894X [Print] England |
PMID | 17300930
(Publication Type: Journal Article)
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Chemical References |
- Ions
- Stilbenes
- kobophenol A
- Nitrogen
- Oxygen
- Calcium
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Topics |
- Calcium
(metabolism)
- Cell Line, Tumor
- Chemistry, Pharmaceutical
(methods)
- Drug Design
- Drug Screening Assays, Antitumor
- Humans
- Ions
- Membrane Potentials
- Mitochondria
(metabolism)
- Models, Chemical
- Molecular Conformation
- Nitrogen
(chemistry)
- Oxygen
(chemistry)
- Stilbenes
(chemical synthesis, chemistry, pharmacology)
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