Abstract | PURPOSE: METHODS: From a database of 231 members of 15 families, 174 had APOE genotype available for analysis. Logistic regressions on APOE genotype and frontotemporal dementia were performed, using appropriate covariates. RESULTS AND CONCLUSION: FTD was associated with APOE 4 genotype (P=0.0002), myopathy (P=0.0006), and age (P=0.01), but not microtubule associated protein tau (MAPT) H2 haplotype (P=0.5) or gender (0.09) after adjustment for membership in pedigrees with at least one APOE 4 genotype. These data suggest a potential link between APOE 4 genotype and the specific form of frontotemporal dementia found in IBMPFD. The molecular basis of this link bears further investigation. We did not observe an association of frontotemporal dementia and H2 MAPT haplotype.
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Authors | Sarju G Mehta, Giles D J Watts, Jennifer L Adamson, Mike Hutton, Geanie Umberger, Shuling Xiong, Sheena Ramdeen, Mark A Lovell, Virginia E Kimonis, Charles D Smith |
Journal | Genetics in medicine : official journal of the American College of Medical Genetics
(Genet Med)
Vol. 9
Issue 1
Pg. 9-13
(Jan 2007)
ISSN: 1098-3600 [Print] United States |
PMID | 17224685
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoproteins E
- tau Proteins
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Topics |
- Adult
- Apolipoproteins E
(genetics)
- Dementia
(genetics)
- Female
- Genes, Dominant
- Genetic Predisposition to Disease
(genetics)
- Genotype
- Haplotypes
(genetics)
- Humans
- Male
- Middle Aged
- Muscular Diseases
(genetics)
- tau Proteins
(genetics)
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