[Experimental evaluation of the effect of glycine and its phosphorylated derivative on ischemic brain injury].

Abstract

The effect of glycine and its phosphorylated derivative (AKF 90-7) on the ischemic brain injury in experimental animals has been studied. The therapeutic injection of glycine and AKF 90-7 (50 100 mg/kg) increased the survival of laboratory animals under the conditions of ischemia caused by ligation of the carotid artery. In a dose of 50 mg/kg, AKF 90-7 was more effective than glycine in activating enzymes of the antioxidant system and preventing the formation of lipid peroxidation products.

• Authors: L M Makarova, V E Pogorelyĭ
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2006 Nov-Dec Vol. 69 Issue 6 Pg. 24-6 ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 17209459 (Publication Type: English Abstract, Journal Article)

Chemical References

• N-acetylaminoacetic acid 3-dimethoxyphosphoryl-2-hydroxy-1-propyl ester
• Neuroprotective Agents
• Superoxide Dismutase
• Glycine

Topics

• Animals
• Brain Ischemia (drug therapy)
• Enzyme Activation
• Glycine (analogs & derivatives, pharmacology)
• Lipid Peroxidation (drug effects)
• Male
• Neuroprotective Agents (pharmacology, therapeutic use)
• Rats
• Rats, Wistar
• Superoxide Dismutase (metabolism)