[Comparative study of the energy-stabilizing and immunotropic properties of trekrezan and polyoxidon on a bronchopulmonary inflammation model in rats].

Abstract

The energy-stabilizing and immunotropic action of immunomodulants trekrezan (25 mg/kg) and polyoxidon (0.75 mg/kg) was compared in rats with a model bronchopulmonary inflammation induced by the introduction of turpentine into trachea. Both drugs exhibited an energy-stabilizing effect, which was manifested by a decrease in the levels of lactate and the ATP-ADP and AMP hydrolysis products and by an increase in the level of pyruvate and ATP in blood lymphocytes and lung tissues. The energy-stabilizing action of polyoxidon was more pronounced in the lung tissue. The action of this drug was generally the same, but less pronounced than the effect of trekrezan. The parallel experiments showed that trekrezan and polyoxidon normalized the immune status of lymphocytes in rats with the model acute bronchopulmonary inflammation.

• Authors: I V Zarubina, A V Bolekhan, P D Shabanov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2006 Sep-Oct Vol. 69 Issue 5 Pg. 50-4 ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 17153967 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Acetates
• Adjuvants, Immunologic
• Drug Combinations
• Ethanolamines
• Organic Chemicals
• Organophosphorus Compounds
• polyoxydonium
• crezacin

Topics

• Acetates (therapeutic use)
• Adjuvants, Immunologic (therapeutic use)
• Animals
• Bronchopneumonia (chemically induced, drug therapy)
• Drug Combinations
• Ethanolamines (therapeutic use)
• Lymphocytes (drug effects, immunology)
• Male
• Organic Chemicals (therapeutic use)
• Organophosphorus Compounds (toxicity)
• Rats
• Rats, Wistar