Abstract |
Five new prenylated flavonoids (1-5) were isolated from the root bark of Berchemia discolor, collected in Tanzania, along with 10 known compounds, by bioactivity-guided fractionation. The structures of compounds 1-5 were elucidated using various spectroscopic techniques. Of these isolates, compound 4, and the known compounds nitidulin (6), amorphigenin (7), and dabinol (8), exhibited cytotoxic activity when evaluated against a small panel of human cancer cells. Nitidulin (6) was further tested in an in vivo hollow fiber assay and found to be active against LNCaP (human hormone-dependent prostate cancer) cells implanted intraperitoneally, at doses of 10, 20, and 40 mg/kg.
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Authors | Young-Won Chin, Ladislaus K Mdee, Zakaria H Mbwambo, Qiuwen Mi, Hee-Byung Chai, Gordon M Cragg, Steven M Swanson, A Douglas Kinghorn |
Journal | Journal of natural products
(J Nat Prod)
Vol. 69
Issue 11
Pg. 1649-52
(Nov 2006)
ISSN: 0163-3864 [Print] United States |
PMID | 17125241
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Flavonoids
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Topics |
- Antineoplastic Agents, Phytogenic
(chemistry, isolation & purification, pharmacology)
- Cell Line, Tumor
- Drug Screening Assays, Antitumor
- Flavonoids
(chemistry, isolation & purification, pharmacology)
- Humans
- Male
- Molecular Structure
- Plant Bark
(chemistry)
- Plant Roots
(chemistry)
- Plants, Medicinal
(chemistry)
- Prostatic Neoplasms
- Rhamnaceae
(chemistry)
- Tanzania
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