Cholestatic syndromes.

Abstract

Further insights into the molecular regulation of bile acid transport and metabolism have provided the basis for a better understanding of the pathogenesis of cholestatic liver diseases. Novel insights into the mechanisms of action of ursodeoxycholic acid should advance our understanding of the treatment of cholestatic liver diseases. Mutations of transporter genes can cause hereditary cholestatic syndromes in both infants and adults as well as cholesterol gallstone disease. Important studies have been published on the pathogenesis, clinical features, and treatment of primary biliary cirrhosis, drug-induced cholestasis, and cholestasis of pregnancy.

• Authors: Michael Trauner, James L Boyer
• Journal: Current opinion in gastroenterology (Curr Opin Gastroenterol) Vol. 18 Issue 3 Pg. 314-29 (May 2002) ISSN: 0267-1379 [Print] United States
• PMID: 17033302 (Publication Type: Journal Article)