[Oxidative metabolism parameters in newborns with sepsis during the cerebral ischemia of different degrees].

Abstract

Within the last decade neonatal sepsis remains one of the actual problems of medicine due to its high morbidity and lethality rates. Reference data clarify that in septicaemia pathogenesis a great importance is attributed to the cellular oxidation-reduction imbalance and oxide stress development. A redox imbalance developed during sepsis indicates to the cell's dysfunction. Also central nervous system is one of the first organs, which is damaged during the sepsis. The purpose of our research was the investigation of activity of pro- and antioxidant system in newborn babies with sepsis during the cerebral ischemia of different degrees. It was shown that during the newborns' sepsis the intensity of free-radical oxidation-reduction process was increased remarkably, antioxidant system activity decreased and intensive ESR-signal of HbNO MetHb was fixed in the blood. These changes caused to development of hypoxemia and deep cerebral ischemia.

• Authors: N E Sanodze, N P Uberi, T V Sanikidze, E N Uberi
• Journal: Georgian medical news (Georgian Med News) Issue 137 Pg. 74-7 (Aug 2006) ISSN: 1512-0112 [Print] Georgia (Republic)
• PMID: 16980751 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Glycated Hemoglobin A
• hemoglobin A, glycosylated-nitric oxide complex
• Nitric Oxide
• Methemoglobin

Topics

• Antioxidants (analysis, metabolism)
• Brain Ischemia (complications, metabolism)
• Glycated Hemoglobin
• Humans
• Infant, Newborn
• Methemoglobin (analysis)
• Nitric Oxide (blood)
• Oxidation-Reduction
• Oxidative Stress
• Sepsis (complications, metabolism)