[Steroid-aggravated rosacea: successful therapy with pimecrolimus].

Abstract

Steroid-induced erythema in rosacea is a therapeutic challenge because of its tendency to rebound and the local characteristics of the facial skin. We describe 3 cases of steroid-induced rosacea with the typical history of steroid abuse with tachyphylaxis. Steroids with increasing potency had to be used with increasing frequency in the course of treatment in order to achieve a response. Acute exacerbations followed any attempt at withdrawal. The steroid treatment was discontinued and therapy with pimecrolimus cream 1% twice daily initiated. This brought rapid and marked improvement within a few days. The cases show that the calcineurin antagonist pimecrolimus offers an effective and well-tolerated therapy option in the acute therapy of steroid-aggravated facial dermatoses.

• Authors: N Meykadeh, F Meiss, W C Marsch, M Fischer
• Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (Hautarzt) Vol. 58 Issue 4 Pg. 338-42 (Apr 2007) ISSN: 0017-8470 [Print] Germany
• Vernacular Title: Steroidaggravierte Rosazea: Erfolgreiche Therapie mit Pimecrolimus.
• PMID: 16874534 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Dermatologic Agents
• Steroids
• pimecrolimus
• Tacrolimus

Topics

• Aged
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Dermatologic Agents (therapeutic use)
• Female
• Humans
• Middle Aged
• Rosacea (chemically induced, drug therapy)
• Steroids (adverse effects, therapeutic use)
• Tacrolimus (analogs & derivatives, therapeutic use)
• Treatment Outcome