Abstract | OBJECTIVE: Chronic administration of moderate amounts of red wine has been associated with a protective effect on the cardiovascular system. This study examined whether red wine polyphenols prevent the angiotensin II (Ang II)-induced hypertension and endothelial dysfunction in rats, and, if so, to elucidate the underlying mechanism. METHODS: Hypertensive rats were obtained by a 14-day infusion of Ang II. Red wine polyphenols were administered in the drinking water one week before and during the Ang II infusion. Arterial pressure was measured in conscious rats. Ex vivo vascular relaxation was assessed in organ chambers, vascular superoxide anion production by dihydroethidine and vascular NADPH oxidase expression by immunohistochemistry. RESULTS: CONCLUSION: Intake of red wine polyphenols prevents Ang II-induced hypertension and endothelial dysfunction. Prevention of vascular NADPH oxidase induction and preservation of arterial nitric oxide availability during Ang II administration likely contribute to this effect.
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Authors | Mamadou Sarr, Marta Chataigneau, Sandrine Martins, Christa Schott, Jasser El Bedoui, Min-Ho Oak, Bernard Muller, Thierry Chataigneau, Valérie B Schini-Kerth |
Journal | Cardiovascular research
(Cardiovasc Res)
Vol. 71
Issue 4
Pg. 794-802
(Sep 01 2006)
ISSN: 0008-6363 [Print] England |
PMID | 16822492
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Flavonoids
- Phenols
- Polyphenols
- Vasodilator Agents
- Superoxides
- Angiotensin II
- Nitroprusside
- Phenylephrine
- Nitric Oxide
- NADPH Oxidases
- Acetylcholine
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Topics |
- Acetylcholine
(pharmacology)
- Angiotensin II
(pharmacology)
- Animals
- Endothelium, Vascular
(drug effects, metabolism, physiopathology)
- Flavonoids
(pharmacology)
- Hypertension
(etiology, metabolism, prevention & control)
- Immunohistochemistry
- Male
- NADPH Oxidases
(analysis, metabolism)
- Nitric Oxide
(metabolism)
- Nitroprusside
(pharmacology)
- Phenols
(pharmacology)
- Phenylephrine
- Polyphenols
- Rats
- Rats, Wistar
- Superoxides
(metabolism)
- Vasodilator Agents
(pharmacology)
- Wine
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