Abstract | BACKGROUND: METHODS: RESULTS: After antigenic challenge a marked drop in body temperature as well as a rapid decrease in serum MBL levels were observed. The decrease of serum MBL levels in shock could not be attributed to MBL binding to immune complexes or tissues, but an interaction of MBL with mast cell-derived proteoglycans was seen. In contrast to mast cell-deficient mice, none of the complement-deficient mouse strains were protected from shock-associated hypothermia. CONCLUSIONS: These results indicate that neither MBL nor activation of the complement cascade is crucial for the induction of anaphylaxis. In contrast mast cell activation is associated with the development of hypothermia and possibly the observed decrease in serum MBL levels.
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Authors | Michaela Windbichler, Bernd Echtenacher, Kazue Takahashi, R Alan B Ezekowitz, Wilhelm J Schwaeble, Jens C Jenseniuis, Daniela N Männel |
Journal | International archives of allergy and immunology
(Int Arch Allergy Immunol)
Vol. 141
Issue 1
Pg. 11-23
( 2006)
ISSN: 1018-2438 [Print] Switzerland |
PMID | 16804320
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2006 S. Karger AG, Basel. |
Chemical References |
- Mannose-Binding Lectin
- Proteoglycans
- RNA, Messenger
- Ovalbumin
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Topics |
- Anaphylaxis
(blood, immunology, physiopathology)
- Animals
- Complement Activation
- Enzyme-Linked Immunosorbent Assay
- Female
- Hypothermia
(etiology, physiopathology)
- Immunohistochemistry
- Mannose-Binding Lectin
(blood, metabolism)
- Mast Cells
(immunology)
- Mice
- Mice, Inbred DBA
- Mice, Mutant Strains
- Ovalbumin
(immunology)
- Polymerase Chain Reaction
- Proteoglycans
(immunology)
- RNA, Messenger
(analysis)
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