Abstract | BACKGROUND: METHODS: CC531 colon carcinoma (2,5 x 106 cells), implanted intraperitoneally in Wag/Rija rats, was treated by hyperthermic intraperitoneal chemotherapy. After 10 days of tumor growth the animals were randomized into five groups of six animals each: group I: control (n = 6), group II: sham operated animals (n = 6), group III: hyperthermic intraperitoneal perfusion (HIP) without cytostatic drugs, group IV: HIPEC with mitomycin C in a concentration of 15 mg/m2 (n = 6), group V: mitomycin C i.p. alone in a concentration of 10 mg/m2 (n = 6). After 10 days the extent of tumor spread and histological outcome were analysed by autopsy. RESULTS: All control animals developed extensive intraperitoneal tumor growth. Histological tumor load was significantly reduced in group III and group V and was lowest in group IV. In group II tumor load was significantly higher than in group I. Implanted metastases were significantly decreased in group IV compared with group I and group II. CONCLUSION:
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Authors | Joerg O W Pelz, J Doerfer, A Dimmler, W Hohenberger, T Meyer |
Journal | BMC cancer
(BMC Cancer)
Vol. 6
Pg. 162
(Jun 22 2006)
ISSN: 1471-2407 [Electronic] England |
PMID | 16792796
(Publication Type: Comparative Study, Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Mitomycin
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Topics |
- Adenocarcinoma
(drug therapy, pathology, secondary, therapy)
- Animals
- Antineoplastic Agents
(administration & dosage, therapeutic use)
- Apoptosis
(drug effects)
- Cell Survival
- Chemotherapy, Cancer, Regional Perfusion
- Colonic Neoplasms
(pathology)
- Combined Modality Therapy
- Dose-Response Relationship, Drug
- Hyperthermia, Induced
- Laparotomy
- Male
- Mitomycin
(administration & dosage, therapeutic use)
- Neoplasm Transplantation
- Neoplasm, Residual
- Peritoneal Cavity
- Peritoneal Neoplasms
(drug therapy, pathology, secondary, therapy)
- Random Allocation
- Rats
- Rats, Wistar
- Specific Pathogen-Free Organisms
- Tumor Burden
(drug effects)
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