The effects of prostaglandin E-1 in patients with intermittent claudication.

Abstract

Aim of the study is to evaluate the effects of Prostaglandin E-1 (PGE-1) in patients with peripheral arterial disease (PAD) at the 2nd b stage Fontaine's classification. The study, controlled, single blinded, enrolled 123 patients with intermittent claudication that were randomised in two groups; the first group received a treatment with PGE-1 while the second one received a pentoxifylline-buflomedil association by venous infusion. We evaluated: Pain Free Walking Distance (PFWD), Maximum Walking Distance (MWD), Rest Flow (RF), Peak Flow (PF), Basal (BVR) and Minimal Vascular Resistance (MVR) with a strain gauge plethysmograph, Resting Flow (RF), Peak Flow (PF), time to reach the Peak Flow (tPF) and time to recovery of the base values (tRF) with laser Doppler flowmeter. After a four weeks treatment, we observed an increase of 370% about PFWD and of 260% in the MWD in patients treated with PGE-1; the other group showed an increase of 110% and 118% respectively. Moreover, the patients of the first group showed a significant increase regarding the plethysmographic Peak Flow (from 9.75+/-1.37 to 16.21+/-1.75, p<0.001), greater than the one observed in the second group (from 9.53+/-1.41 to 13.47+/-1.53, p<0.05); also the laser Doppler parameters showed a significant reduction, more evident in the first group (tPF from 23.0+/-7.5 to 10.5+/-4.9, p<0.001; tRF from 73.5+/-22.7 to 48.3+/-13.5, p<0.001) than in the second one.

• Authors: Glauco Milio, Giuseppe Coppola, Salvatore Novo
• Journal: Cardiovascular & hematological disorders drug targets (Cardiovasc Hematol Disord Drug Targets) Vol. 6 Issue 2 Pg. 71-6 (Jun 2006) ISSN: 1871-529X [Print] United Arab Emirates
• PMID: 16787192 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Drug Combinations
• Pyrrolidines
• Vasodilator Agents
• Alprostadil
• Pentoxifylline
• buflomedil

Topics

• Adult
• Aged
• Alprostadil (administration & dosage, therapeutic use)
• Drug Combinations
• Exercise Test
• Female
• Humans
• Infusions, Intravenous
• Intermittent Claudication (drug therapy, physiopathology)
• Laser-Doppler Flowmetry
• Male
• Middle Aged
• Pentoxifylline (administration & dosage, therapeutic use)
• Plethysmography
• Pyrrolidines (administration & dosage, therapeutic use)
• Regional Blood Flow (drug effects)
• Severity of Illness Index
• Treatment Outcome
• Vascular Resistance (drug effects)
• Vasodilator Agents (administration & dosage, therapeutic use)
• Walking (physiology)