Localized cutaneous polyvinylpyrrolidone storage disease mimicking cheilitis granulomatosa.

Abstract

Polyvinylpyrrolidone (PVP), a polymer of the monomer N-vinylpyrrolidone with various molecular weights, was originally developed as a plasma expander. Currently, it is widely used in hair sprays, skin care products, fruit juices, and as a retarding agent in drugs such as procaine and hormones. PVP polymers with a molecular weight greater than 20,000 cannot be excreted by the kidneys and therefore are phagocytosed and permanently stored in the reticular endothelial system, leading to the so-called PVP storage disease. We report a case of localized cutaneous PVP storage disease presenting with persistent upper lip swelling and mimicking cheilitis granulomatosa, which has never been reported before.

• Authors: Ching-Chi Chi, Shu-Hui Wang, Tseng-tong Kuo
• Journal: Journal of cutaneous pathology (J Cutan Pathol) Vol. 33 Issue 6 Pg. 454-7 (Jun 2006) ISSN: 0303-6987 [Print] United States
• PMID: 16776723 (Publication Type: Case Reports, Journal Article)

Chemical References

• Pharmaceutic Aids
• Povidone

Topics

• Cheilitis (chemically induced, metabolism, pathology)
• Diagnosis, Differential
• Female
• Granuloma (chemically induced, metabolism, pathology)
• Histiocytes (drug effects, metabolism, pathology)
• Humans
• Middle Aged
• Phagocytosis (drug effects)
• Pharmaceutic Aids (adverse effects, metabolism)
• Povidone (adverse effects, metabolism)
• Skin Diseases (chemically induced, metabolism, pathology)