Reversible tremor, myoclonus, and fasciculations associated with topiramate use for migraine.

Abstract

OBJECTIVE:

To report a patient with tremor, multifocal myoclonus, and fasciculations, possibly induced by the antiepileptic drug topiramate.

CASE REPORT:

A 46-year-old woman with frequent episodes of migraine without aura that were not controlled with other prophylactic drug, developed a reversible clinical picture of postural tremor, multifocal myoclonus, weight loss, amyotrophia, and fasciculations after exposure to topiramate. These symptoms disappeared after topiramate withdrawal.

CONCLUSIONS:

Tremor, myoclonus, and fasciculations should be considered as a possible adverse effect of topiramate.

• Authors: Hortensia Alonso-Navarro, Félix Javier Jiménez-Jiménez
• Journal: Clinical neuropharmacology (Clin Neuropharmacol) 2006 May-Jun Vol. 29 Issue 3 Pg. 157-9 ISSN: 0362-5664 [Print] United States
• PMID: 16772816 (Publication Type: Case Reports, Journal Article)

Chemical References

• Topiramate
• Fructose

Topics

• Fasciculation (chemically induced, physiopathology)
• Female
• Fructose (adverse effects, analogs & derivatives)
• Humans
• Middle Aged
• Migraine Disorders (drug therapy, physiopathology)
• Myoclonus (chemically induced, physiopathology)
• Topiramate
• Tremor (chemically induced, physiopathology)