Dementia with mood symptoms in a fragile X premutation carrier with the fragile X-associated tremor/ataxia syndrome: clinical intervention with donepezil and venlafaxine.

Abstract	The authors present a case of a patient with dementia with mood symptoms and multiple neurological manifestations of fragile X-associated tremor/ataxia syndrome (FXTAS). Despite a gradually deteriorating neurological course, he was managed for 2 years with combination therapy of donepezil and venlafaxine, which resulted in improvement and relative stabilization of his psychiatric status. Psychiatrists are hereby alerted to the description of a novel dementia syndrome that may respond to pharmacological intervention commonly used for other dementias.
Authors	James A Bourgeois, Faraz Farzin, James A Brunberg, Flora Tassone, Paul Hagerman, Lin Zhang, David Hessl, Randi Hagerman
Journal	The Journal of neuropsychiatry and clinical neurosciences (J Neuropsychiatry Clin Neurosci) Vol. 18 Issue 2 Pg. 171-7 ( 2006) ISSN: 0895-0172 [Print] United States
PMID	16720793 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural)
Chemical References	Antidepressive Agents, Second-Generation Cyclohexanols FMR1 protein, human Indans Nootropic Agents Piperidines Fragile X Mental Retardation Protein Venlafaxine Hydrochloride Donepezil
Topics	Aged Antidepressive Agents, Second-Generation (therapeutic use) Ataxia (diagnosis, drug therapy, genetics) Atrophy Brain (pathology) Cyclohexanols (therapeutic use) Dementia (diagnosis, drug therapy, genetics) Dominance, Cerebral (physiology) Donepezil Dose-Response Relationship, Drug Drug Therapy, Combination Fragile X Mental Retardation Protein (genetics) Fragile X Syndrome (diagnosis, drug therapy, genetics) Genetic Carrier Screening Humans Image Processing, Computer-Assisted Indans (therapeutic use) Magnetic Resonance Imaging Male Mental Status Schedule Mood Disorders (diagnosis, drug therapy, genetics) Neurologic Examination Neuropsychological Tests Nootropic Agents (therapeutic use) Piperidines (therapeutic use) Tremor (diagnosis, drug therapy, genetics) Trinucleotide Repeats Venlafaxine Hydrochloride

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