[Simultaneous liver-pancreas-duodenum transplantation: one case report and review of the literature].

Abstract

OBJECTIVE:

To investigate the effect of treatment on end-stage liver disease and type-I diabetes mellitus with simultaneous liver-pancreas-duodenum transplantation.

METHOD:

In September 2003, one patient with chronic hepatitis B, liver cirrhosis, hepatic cellular cancer, and insulin-dependent diabetes received simultaneous orthotopic liver and heterotopic pancreas-duodenum transplantation. Liver and pancreas graft function was monitored after transplantation.

RESULTS:

The function of pancreas allograft was recovered immediately and the patient became insulin-independence postoperatively. The liver allograft was experienced an acute rejection episode and reversed by intravenous bolus methylprednisolone. The recipient was currently liver disease-free and insulin-free more than 21 months.

CONCLUSIONS:

The simultaneous liver-pancreas-duodenum transplantation is an effective method in the treatment of end-stage liver disease and type-I diabetes mellitus.

• Authors: Jian Xu, Li-xin Yu, Wen-feng Deng, Shao-jie Fu, Chuan-fu Du, Yi-bin Wang, Xiao-you Liu, Yun Miao, Chuan-jiang Li, Jun-sheng Ye
• Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] (Zhonghua Wai Ke Za Zhi) Vol. 44 Issue 3 Pg. 157-60 (Feb 01 2006) ISSN: 0529-5815 [Print] China
• PMID: 16635342 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Immunosuppressive Agents

Topics

• Diabetes Mellitus, Type 1 (complications, surgery)
• Duodenum (transplantation)
• Female
• Follow-Up Studies
• Graft Rejection (prevention & control)
• Humans
• Immunosuppressive Agents (therapeutic use)
• Liver Cirrhosis (complications, surgery)
• Liver Neoplasms (complications, surgery)
• Liver Transplantation
• Male
• Middle Aged
• Pancreas Transplantation
• Transplantation, Homologous