[Effect of Shenkangwan on mesangial cell NO and TGF-beta1 excretion in rats with early diabetic nephropathy].

Abstract

OBJECTIVE:

To study the mechanism of Shenkangwan (SKW) in treating early diabetic nephropathy (DN).

METHODS:

The effect of SKW on NO and transforming growth factor (TGF)-beta(1) production by the mesangial cells (MCs) of rats with early diabetic nephropathy was evaluated with serum pharmacological method.

RESULTS:

Compared with normal serum, the SKW-containing serum dose- and time-dependently inhibited TGF-beta(1) excretion and increased NO production in the MCs of rats with early DN (P<0.05 and P<0.01, respectively).

CONCLUSION:

The therapeutic effect of SKW on early DN may rely on the balance modulation of cytokine network by increasing NO production and decreasing TGF-beta(1) excretion to prevent cytokine-induced damage of the MCs.

• Authors: Guo-bao Chen, Lian-bo Wei, Wei Xiao, Hai-bo Long
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 26 Issue 4 Pg. 526-8 (Apr 2006) ISSN: 1673-4254 [Print] China
• PMID: 16624774 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drugs, Chinese Herbal
• Transforming Growth Factor beta
• Nitric Oxide

Topics

• Animals
• Diabetes Mellitus, Experimental (drug therapy, metabolism)
• Diabetic Nephropathies (drug therapy, metabolism)
• Drugs, Chinese Herbal (therapeutic use)
• Glomerular Mesangium (metabolism, pathology)
• Male
• Nitric Oxide (biosynthesis)
• Rats
• Rats, Wistar
• Transforming Growth Factor beta (biosynthesis)