Abstract | AIMS/HYPOTHESIS: METHODS: A population-based cohort of more than 140,000 Austrian adults (63,585 men, 77,228 women) was followed over an average of 8.4 years. Incident cancer (other than non- melanoma skin cancers) was ascertained by a population-based cancer registry (n=5,212). Cox proportional-hazards models were used to estimate hazard rate ratios (HR) stratified for age and adjusted for smoking, occupational group and body mass index. RESULTS: The highest fasting blood glucose category (> or =7.0 mmol/l) was weakly associated with all cancers combined (HR 1.20; 95% CI, 1.03-1.39 in men and 1.28; 95% CI, 1.08-1.53 in women) relative to the reference level (4.2-5.2 mmol/l). The strongest association was found for liver cancer in men (HR 4.58; 95% CI, 1.81-11.62). Positive associations between fasting hyperglycaemia (6.1-6.9 or > or =7.0 mmol/l) and cancer incidence were also observed for non-Hodgkin's lymphoma in men, and for colorectal and bladder cancer in women. Breast cancer in women diagnosed at or after age 65 was also associated with fasting blood glucose > or =7.0 mmol/l. Positive associations with glucose values >5.3 mmol/l were noted for thyroid cancer, gallbladder/ bile duct cancer and multiple myeloma in men and women combined. CONCLUSIONS/INTERPRETATION: These findings provide further evidence that elevated blood glucose is associated with the incidence of several types of cancer in men and women.
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Authors | K Rapp, J Schroeder, J Klenk, H Ulmer, H Concin, G Diem, W Oberaigner, S K Weiland |
Journal | Diabetologia
(Diabetologia)
Vol. 49
Issue 5
Pg. 945-52
(May 2006)
ISSN: 0012-186X [Print] Germany |
PMID | 16557372
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Austria
(epidemiology)
- Blood Glucose
(analysis)
- Body Mass Index
- Cohort Studies
- Fasting
- Female
- Humans
- Male
- Neoplasms
(epidemiology)
- Proportional Hazards Models
- Risk Assessment
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