Abstract | OBJECTIVE: Oxidative stress is an intrinsic part of the chain of events leading to inflammation of the airways caused by bacterial infection. The aim of this study was to determine whether analysis of exhaled breath condensate from patients with severe lung infections reveals changes in the redox state at the airway surface. PATIENTS AND METHODS: RESULTS: Significant differences in the concentrations of nitrite, 8-isoprostane, and MPO were observed between patients and individuals without respiratory disease but no differences were found between the 3 patient groups. The concentration of MPO was correlated with the concentrations of 8-isoprostane and nitrate, which were normalized to the nitrite concentration. CONCLUSIONS: Analysis of the concentrations of 8-isoprostane and MPO in exhaled breath condensate allows assessment of oxidative stress in the airways of patients with severe lung infections.
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Authors | P V Romero, B Rodríguez, S Martínez, R Cañizares, D Sepúlveda, F Manresa |
Journal | Archivos de bronconeumologia
(Arch Bronconeumol)
Vol. 42
Issue 3
Pg. 113-9
(Mar 2006)
ISSN: 0300-2896 [Print] Spain |
Vernacular Title | Estrés oxidativo en el condensado exhalado de pacientes con infección pulmonar grave. |
PMID | 16545248
(Publication Type: English Abstract, Journal Article)
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Topics |
- Adult
- Aged
- Breath Tests
(instrumentation)
- Exhalation
- Female
- Humans
- Male
- Middle Aged
- Oxidative Stress
- Pneumonia, Bacterial
(metabolism)
- Severity of Illness Index
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